gadolinium complex造句

• Neutron capture therapy; liposome; gadolinium complex; tumor cell
  中子俘获治疗脂质体钆配合物癌细胞
• Liposome is an effective nuclide delivery agent for neutron capture therapy . in this paper liposomes containing encapsulated gadolinium complex were prepared and characterized . the influence of formulation factors such as ph, ionic strength, buffer, and storage time upon the stability of liposomes was investigated . the uptake rate constant and its concentration dependence of lgd in tumor cells were compared in vitro with that of gd complex itself . the results indicate that the uptake rate of lgd in tumor cells increases to eight times as much as that of gd-edta, but the release rate of gd from tumor cells containing lgd is remarkably lower than that from the tumor cells containing gd-edta . the results reveal that lgd would be a potential drug for neutron capture therapy of cancer
  制备和表征了包埋gd-edta的脂质体，测定了ph，离子强度，缓冲液组成及温度对gd-edta脂质体的影响，比较了gd-edta脂质体和gd-edta被肿瘤细胞摄入的动力学曲线。结果表明，gd-edta脂质体在37和生理条件下最稳定，肿瘤细胞摄入gd-edta脂质体速率是gd-edta的8倍，而释放gd的速率，gd-edta脂质体远远低于gd-edta,这些结果提供了脂质体包埋gd-edta作为钆中子俘获治疗药物的可能性。